The Savvygen™ GI Astrovirus test allows the qualitative detection of Astrovirus by real time RT-PCR in human feces. The product is intended for use in the diagnosis of Astrovirus gastrointestinal infections alongside clinical data of the patient and other laboratory tests outcomes.
Human Astroviruses (HAstV) are one of the most important causes of acute pediatric gastroenteritis. Classic Astroviruses can also be classified into eight genotypes, which correspond with eight serotypes. Type 1 is the most prevalent worldwide. Classic HAstVs are distributed all over the world and are associated with 2 to 9% of cases of acute, nonbacterial diarrhea in children. HAstVs affect predominantly the pediatric population although infections in elderly people and immunocompromised hosts are also reported. Astroviruses are transmitted by the fecal-oral route, and outbreaks have been associated with consumption of sewage-polluted water and food. Typically, HAstV infection induces a mild, watery diarrhea that lasts 2 to 3 days, associated with vomiting, fever, anorexia, and abdominal pain. The genome of human Astrovirus is composed of single-stranded, positive-sense RNA which encodes three open reading frames (ORFs), named ORF1a, ORF1b, and ORF2, being the ORF1b the best target for detection of Astrovirus.
The Savvygen™ GI Astrovirus test is a ready-to used test which contains in each well all the necessary reagents for real time PCR assay in a stabilized format. In addition, an internal control allows the detection of a possible reaction inhibition. The amplification of the target sequence is detected through the FAM channel whereas the internal control (IC) in HEX channel.
| Catalog No | Product name | Tests/kit | Approvals |
| 609-01 | Savvygen Astrovirus | 48 | CE |