The COMP® ELISA is a quantitative enzyme-linked immunosorbent assay
for the determination of Cartilage Oligomeric Matrix Protein (COMP) in human
serum.
The presence of elevated levels, when considered in conjunction
with other laboratory and clinical findings, is an aid in identifying
aggressive destruction of joint tissue in diseases such as rheumatoid arthritis
(RA).
It is well documented that when articular cartilage matrix is
degraded by a disease process, protein fragments are produced and diffuse out
into the joint fluid. Some of these proteins, such as COMP, subsequently appear
in the bloodstream and can be used to monitor the progress of cartilage
degradation in inflammatory joint diseases such as rheumatoid arthritis1, 2 and
osteoarthritis3.
A quantitative relation has been shown between the
concentrations of COMP in serum and cartilage degradation using radiographic
changes as a surrogate clinical endpoint.
The following guidelines may be used to assess ongoing
cartilage turnover and the risk of joint destruction in the future:
· < 12 U/L Lower risk of
aggressive joint destruction
· 12-15 U/L Increasing risk of
aggressive joint destruction
· > 15 U/L High risk of
aggressive joint destruction
Kit Info
|
Code: |
AN-14-1006-71 |
|
Certification: |
CE Marked |
|
Clinical
Area: |
Cartilage
Markers |
|
Type: |
Manual |
|
Format: |
ELISA |
|
RUO/IVD: |
IVD |
|
Number
of Tests: |
96
(40 samples in duplicate) |
|
Sample
Type: |
Serum,
Heparin Plasma |
|
Sample
Volume: |
25
μL (pre-diluted 1/10) |
|
Assay
Range: |
N/A |
Dénarié D et al., Could biomarkers of bone, cartilage or
synovium turnover be used for relapse prediction in rheumatoid arthritis
patients? Mediators Inflamm. 2014;2014:537324.
Turesson C et al., Increased cartilage turnover and circulating
auto-antibodies in different subsets before the clinical onset of rheumatoid
arthritis. Ann Rheum Dis. 2011;70:520-522.
Sowers MF et al., Longitudinal changes of serum COMP and urinary
CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in
women.
Bone Markers
Urine CartiLaps
ELISA